Eisen H, Furusawa M, Tanabe K, Takada S, Ostertag W
Bull World Health Organ. 1977;55(2-3):367-72.
The ability of Plasmodium chabaudi and P. yoelii to bind to Friend erythroleukemia cells in vitro was examined. Extensive binding of P. yoelii and weaker binding of P. chabaudi was observed. Binding to mouse fibroblasts was not seen, although there was some binding to cells of a mouse mastocytoma. The binding of P. yoelii to Friend cells was sensitive to specific antiserum. The development of P. berghei and P. yoelii in Friend cells was followed by microscopic examination and measurement of the infectivity of those cells in mice. Friend cells infected with both species appeared to develop morphologically normal intracellular forms of the parasites. P. yoelii-infected cells were infective in sensitive mice for 3 days after addition of the parasites, and this infectivity was not sensitive to treatment in vitro with mouse anti-P. yoelii serum.
检测了查巴迪疟原虫和约氏疟原虫在体外与弗氏红白血病细胞结合的能力。观察到约氏疟原虫有广泛的结合，而查巴迪疟原虫的结合较弱。未观察到与小鼠成纤维细胞的结合，不过与小鼠肥大细胞瘤的细胞有一些结合。约氏疟原虫与弗氏细胞的结合对特异性抗血清敏感。通过显微镜检查以及测量这些细胞在小鼠体内的感染性，追踪了伯氏疟原虫和约氏疟原虫在弗氏细胞中的发育情况。感染这两种疟原虫的弗氏细胞似乎都发育出形态正常的细胞内寄生虫形态。添加寄生虫后，感染约氏疟原虫的细胞在敏感小鼠体内3天具有感染性，且这种感染性对用小鼠抗约氏疟原虫血清进行的体外处理不敏感。
