热量限制与细胞衰老。

Caloric restriction and cellular senescence.

机构信息

Charles Perkins Centre and Central Clinical School, The University of Sydney, Australia; Department of Medicine, Washington University School of Medicine, St. Louis, USA; Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy.

University of Groningen, European Research Institute for the Biology of Aging, University Medical Center Groningen, Groningen, Netherlands; Lebanese University, Doctoral School of Science and Technology, Hadath, Beirut, Lebanon.

出版信息

Mech Ageing Dev. 2018 Dec;176:19-23. doi: 10.1016/j.mad.2018.10.005. Epub 2018 Nov 3.

DOI:10.1016/j.mad.2018.10.005

PMID:30395873

Abstract

Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and secretion of various bioactive molecules, a phenomenon defined the Senescence-Associated Secretory Phenotype (SASP). Senescent cells are implicated in a number of biological functions, from embryogenesis to aging. Significantly, excessive accumulation of senescent cells is associated to a decline of regenerative capacity and chronic inflammation. In accordance, the removal of senescent cells is sufficient to delay several pathologies and promote healthspan. Calorie restriction (CR) without malnutrition is currently the most effective non-genetic intervention to delay aging phenotypes. Recently, we have shown that CR can prevent accumulation of senescent cells in both mice and humans. Here, we summarize the current knowledge on the molecular and cellular events associated with CR, and define how these events can interfere with the induction of cellular senescence. We discuss the potential side effects of preventing senescence, and the possible alternative dietary interventions with potential senolytic properties.

摘要

细胞衰老（Cellular senescence）是一种不可逆的生长停滞状态，其特征是细胞肥大和各种生物活性分子的分泌，这一现象被定义为衰老相关分泌表型（Senescence-Associated Secretory Phenotype，SASP）。衰老细胞参与了许多生物学功能，从胚胎发生到衰老。重要的是，衰老细胞的过度积累与再生能力下降和慢性炎症有关。因此，清除衰老细胞足以延缓多种疾病并促进健康寿命。目前，限制热量摄入（Calorie restriction，CR）而不造成营养不良是延缓衰老表型的最有效非遗传干预措施。最近，我们已经表明 CR 可以防止小鼠和人类衰老细胞的积累。在这里，我们总结了与 CR 相关的分子和细胞事件的最新知识，并定义了这些事件如何干扰细胞衰老的诱导。我们讨论了预防衰老的潜在副作用，以及具有潜在衰老细胞溶解特性的可能替代饮食干预措施。