靶向癫痫中的缝隙连接：观点与挑战。

Targeting gap junction in epilepsy: Perspectives and challenges.

机构信息

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, Hunan, China.

出版信息

Biomed Pharmacother. 2019 Jan;109:57-65. doi: 10.1016/j.biopha.2018.10.068. Epub 2018 Nov 2.

DOI:10.1016/j.biopha.2018.10.068

PMID:30396092

Abstract

Gap junctions (GJs) are multiple cellular intercellular connections that allow ions to pass directly into the cytoplasm of neighboring cells. Electrical coupling mediated by GJs plays a role in the generation of highly synchronous electrical activity. Accumulative investigations show that GJs in the brain are involved in the generation, synchronization and maintenance of seizure events. At the same time, GJ blockers exert potent curative potential on epilepsy in vivo or in vitro. This review aims to shed light on the role of GJs in epileptogenesis. Targeting GJs is likely to be served as a novel therapeutic approach on epileptic patients.

摘要

间隙连接（GJ）是多个细胞间的连接，允许离子直接进入相邻细胞的细胞质。由 GJ 介导的电偶联在产生高度同步的电活动中起作用。累积的研究表明，大脑中的 GJ 参与了癫痫发作的产生、同步和维持。同时，GJ 阻断剂在体内或体外对癫痫具有强大的治疗潜力。本综述旨在阐明 GJ 在癫痫发生中的作用。针对 GJ 可能成为癫痫患者的一种新的治疗方法。