Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 07738, Mexico.
Int J Mol Sci. 2023 Mar 30;24(7):6488. doi: 10.3390/ijms24076488.
Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy. Both clinical and preclinical studies show that TAL may act as an antiepileptic drug and as a possible treatment against disease development. However, the evidence for these effects is limited. Therefore, the antiepileptogenic and anti-inflammatory effects of TAL were evaluated herein. Sprague Dawley male rats were randomly allocated to one of five groups (n = 18 per group): control (C); status epilepticus (SE); SE-TAL (25 mg/kg); SE-TAL (50 mg/kg); and SE-topiramate (TOP; 60mg/kg). The lithium-pilocarpine model was used, and one day after SE induction the rats received pharmacological treatment for one week. The brain was obtained, and the hippocampus was micro-dissected 8, 18, and 28 days after SE. TNF-α, IL-6, and IL-1β concentrations were quantified. TOP and TAL (50 mg/kg) increased the latency to the first of many spontaneous recurrent seizures (SRS) and decreased SRS frequency, as well as decreasing TNF-α and IL-1β concentrations in the hippocampus. In conclusion, the results showed that both TAL (50 mg/kg) and TOP have anti-ictogenic and antiepileptogenic effects, possibly by decreasing neuroinflammation.
沙利度胺（TAL）在癫痫等神经疾病中显示出潜在的治疗效果。临床和临床前研究表明，TAL 可能作为抗癫痫药物和针对疾病发展的可能治疗方法。然而，这些效果的证据有限。因此，本文评估了 TAL 的抗癫痫发生和抗炎作用。雄性 Sprague Dawley 大鼠随机分为五组（每组 n = 18）：对照组（C）；癫痫持续状态（SE）；SE-TAL（25mg/kg）；SE-TAL（50mg/kg）；SE-托吡酯（TOP；60mg/kg）。使用锂-匹罗卡品模型，在 SE 诱导后一天，大鼠接受药物治疗一周。获得大脑，并在 SE 后 8、18 和 28 天微分离海马体。定量测定 TNF-α、IL-6 和 IL-1β 浓度。TOP 和 TAL（50mg/kg）均延长了首次多次自发性复发癫痫发作（SRS）的潜伏期并降低了 SRS 频率，同时降低了海马体中的 TNF-α 和 IL-1β 浓度。总之，结果表明 TAL（50mg/kg）和 TOP 均具有抗癫痫发生和抗癫痫作用，可能通过减少神经炎症。
