Department of Anatomy, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Gynaecology and Obstetrics, Rijnstate, Arnhem, the Netherlands; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Fertil Steril. 2018 Nov;110(6):1118-1128. doi: 10.1016/j.fertnstert.2018.06.040.
To investigate alterations in tactile, pain thresholds and pain tolerance thresholds in patients with endometriosis using a multimodality approach.
Cross-sectional study.
Multidisciplinary referral center.
PATIENT(S): Women with proven endometriosis (N = 35) and healthy controls (N = 38).
INTERVENTION(S): Pain processing was tested using quantitative sensory testing (QST) to investigate sensation, pain, and pain tolerance thresholds for thermal, electrical, and pressure stimuli.
MAIN OUTCOME MEASURE(S): Differences in QST measures in patients with endometriosis and in healthy controls on the endometriosis site and control sites, and the association between QST outcomes and patient characteristics.
RESULT(S): We observed a significantly decreased pain tolerance in patients with endometriosis, independent of clinical pain intensity or revised American Society for Reproductive Medicine stage, compared with healthy controls.
CONCLUSION(S): Increasing knowledge concerning mechanisms underlying the pain of women with endometriosis creates opportunities to develop new treatment options. More attention should be paid not only to treat endometriosis in a surgical or pharmacologic way, but also to desensitize by pain education or cognitive therapy.
采用多模态方法研究子宫内膜异位症患者触觉、痛觉阈值和痛觉耐受阈值的变化。
横断面研究。
多学科转诊中心。
经证实患有子宫内膜异位症的女性（N=35）和健康对照者（N=38）。
使用定量感觉测试（QST）测试疼痛处理，以研究热、电和压力刺激的感觉、疼痛和痛觉耐受阈值。
子宫内膜异位症患者和健康对照者在子宫内膜异位症部位和对照部位的 QST 测量值差异，以及 QST 结果与患者特征之间的关系。
与健康对照组相比，无论临床疼痛强度或修订后的美国生殖医学学会分期如何，子宫内膜异位症患者的痛觉耐受均显著降低。
增加对子宫内膜异位症女性疼痛机制的了解为开发新的治疗方法创造了机会。不仅应通过手术或药物治疗来治疗子宫内膜异位症，还应通过疼痛教育或认知疗法来脱敏，这一点应引起更多关注。
