血清素前体对清醒大鼠静脉注射可乐定后升压反应的影响。

The effects of serotonin precursors on the pressor response to intravenous clonidine in conscious rats.

Nolan P L

Clin Exp Pharmacol Physiol. 1977 Nov-Dec;4(6):579-83. doi: 10.1111/j.1440-1681.1977.tb02688.x.

Abstract

The interaction of the biosynthetic precursors of serotonin with the alpha-adrenoceptor-mediated pressor response to intravenous clonidine was investigated in unanaesthetized rats. 2. Pretreatment with 100 mg/kg of either L-tryptophan or 5-hydroxytryptophan (5-HTP) reduced the magnitude of the pressor response elicited by intravenous clonidine (25 microgram/kg) to 15% and 11%, respectively, of that observed in control rats. 3. The depression by L-tryptophan of the clonidine-induced pressor response could be prevented by pretreatment with either the L-aromatic amino acid decarboxylase inhibitor Rö44602 or the serotonin antagonist methysergide.

摘要

在未麻醉的大鼠中研究了血清素生物合成前体与α-肾上腺素能受体介导的静脉注射可乐定升压反应之间的相互作用。2. 用100mg/kg的L-色氨酸或5-羟色氨酸（5-HTP）预处理后，静脉注射可乐定（25μg/kg）引起的升压反应幅度分别降至对照大鼠中观察到的15%和11%。3. L-色氨酸对可乐定诱导的升压反应的抑制作用可通过用L-芳香族氨基酸脱羧酶抑制剂Rö44602或血清素拮抗剂麦角新碱预处理来预防。