Sakaguchi Masakuni, Maebayashi Toshiya, Aizawa Takuya, Ishibashi Naoya
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Anticancer Res. 2018 Nov;38(11):6405-6411. doi: 10.21873/anticanres.13001.
To evaluate outcomes of breast cancer patients with confirmed dural metastasis (DM) alone who received whole-brain radiation therapy (WBRT).
The medical records of thirty-three breast cancer patients who received WBRT to treat intracranial metastasis were retrospectively reviewed. The clinical presentation of DM-only was compared with that of brain metastasis (BM)/leptomeningeal metastasis (LM).
Eight patients had DM and 25 patients had BM/LM. Median survival was 12 months in patients with DM and 7 months in those with BM/LM. Multivariate analysis found that only a Karnofsky performance status of ≥70 was significantly associated with improved OS. DM did not cause the death of any patient. Symptoms did not worsen in any DM patient.
WBRT can be considered for patients with DM alone for symptom improvement and preventing DM-related death.
评估仅确诊为硬脑膜转移（DM）的乳腺癌患者接受全脑放射治疗（WBRT）的疗效。
回顾性分析33例接受WBRT治疗颅内转移的乳腺癌患者的病历。将仅DM患者的临床表现与脑转移（BM）/软脑膜转移（LM）患者的临床表现进行比较。
8例患者有DM，25例患者有BM/LM。DM患者的中位生存期为12个月，BM/LM患者为7个月。多因素分析发现，仅卡氏功能状态≥70与总生存期改善显著相关。DM未导致任何患者死亡。任何DM患者的症状均未恶化。
对于仅患有DM的患者，可考虑采用WBRT来改善症状并预防与DM相关的死亡。
