睾丸癌的家族性发病情况。

Familial occurrence of testicular cancer.

作者信息

Buerger R A, von Wallenberg H, Reis M, Engelmann U

出版信息

Urol Int. 1987;42(2):158-60. doi: 10.1159/000281878.

Abstract

A case of testicular cancer in 2 brothers is reported and a review of the literature about testicular malignancies and etiologic factors in closely related family members is given. The familial incidence of testicular tumor is found to be 3% in twins and 0.6-2.1% in less closely related men. Tumors were of the same histology in 70-77% of the twins, whereas in brothers and in other degrees of relationship tumors of different histology mostly occur. Following the diagnosis of the tumor in the first man, the average interval to presentation of the tumor in the relative was 3.7 years in twins, 7.7 years in nontwin brothers and 13.5 years for less closely related men. The need for a thorough checkup of other family members is advised.

摘要

本文报告了2例兄弟患睾丸癌的病例，并对有关睾丸恶性肿瘤及近亲家庭成员病因的文献进行了综述。研究发现，睾丸肿瘤的家族发病率在双胞胎中为3%，在血缘关系较远的男性中为0.6 - 2.1%。70 - 77%的双胞胎患相同组织学类型的肿瘤，而在兄弟及其他亲属关系中，大多发生不同组织学类型的肿瘤。首例患者确诊肿瘤后，其亲属出现肿瘤的平均间隔时间在双胞胎中为3.7年，在非双胞胎兄弟中为7.7年，在血缘关系较远的男性中为13.5年。建议对其他家庭成员进行全面检查。