Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada.
Acquired Brain Injury Research Lab, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Nat Rev Neurol. 2018 Dec;14(12):711-722. doi: 10.1038/s41582-018-0091-y.
Over the past decade, traumatic brain injury (TBI) has emerged as a major public health concern, attracting considerable interest from the scientific community, clinical and behavioural services and policymakers, owing to its rising prevalence, wide-ranging risk factors and substantial lifelong familial and societal impact. This increased attention to TBI has resulted in increased funding and advances in legislation. However, many questions surrounding TBI remain unanswered, including questions on sex and gender trends with respect to vulnerability to injury, presentation of injury, response to treatment, and outcomes. Here, we review recent research efforts aimed at advancing knowledge on the constructs of sex and gender and their respective influences in the context of TBI, and discuss methodological challenges in disentangling the differential impacts of these two constructs, particularly in marginalized populations.
在过去的十年中，创伤性脑损伤（TBI）已成为一个主要的公共卫生关注点，由于其发病率上升、广泛的风险因素以及对个人、家庭和整个社会的终身重大影响，引起了科学界、临床和行为服务以及政策制定者的极大关注。对 TBI 的关注度增加，导致了资金的增加和立法的进步。然而，TBI 仍有许多问题尚未得到解答，包括关于易受伤性、损伤表现、治疗反应和结果方面的性别趋势问题。在这里，我们回顾了最近旨在提高关于性别结构及其各自在 TBI 背景下影响的知识的研究工作，并讨论了在分离这两个结构的差异影响方面的方法学挑战，特别是在边缘化人群中。
