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乳腺神经内分泌癌:病例报告与文献综述

Neuroendocrine Carcinoma of the Breast: Case Report and Literature Review.

作者信息

Lee Yu-Chen, Chen Yao-Li, Chan Szu-Erh, Tseng Hsin-Shun, Chen Dar-Ren

机构信息

Division of General Surgery, Department of Surgery, Yumin Hospital, Nantou, Changhua Christian Hospital, Changhua, Taiwan, Republic of China.

Division of General Surgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan, Republic of China.

出版信息

Breast Care (Basel). 2009 Nov;4(5):324-327. doi: 10.1159/000236226. Epub 2009 Sep 29.

Abstract

BACKGROUND

Neuroendocrine carcinoma of the breast is a rare disease.

CASE REPORT

We present a 65-yearold female patient with an enlarged breast mass within 2 months. Solid neuroendocrine carcinoma of the breast was diagnosed by excision biopsy and histopathological analysis. A lumpectomy with the right axillary sentinel lymph node biopsy was performed, and the mass was completely resected. The literature on neuroendocrine carcinoma of the breast is reviewed.

CONCLUSION

Due to the diversity of imaging findings from primary breast neuroendocrine carcinomas, the diagnosis is based on immunohistochemical staining of neuroendocrine markers. Surgery has turned out to be the first-line treatment and subsequently radiation may play a role in palliative treatment.

摘要

背景

乳腺神经内分泌癌是一种罕见疾病。

病例报告

我们报告一名65岁女性患者,其乳房肿块在2个月内增大。通过切除活检和组织病理学分析诊断为乳腺实性神经内分泌癌。进行了乳房肿块切除术及右侧腋窝前哨淋巴结活检,肿块被完全切除。对乳腺神经内分泌癌的文献进行了综述。

结论

由于原发性乳腺神经内分泌癌影像学表现多样,诊断基于神经内分泌标志物的免疫组化染色。手术已成为一线治疗方法,随后放疗可能在姑息治疗中发挥作用。

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Is detection of endocrine cells in breast adenocarcinoma of diagnostic and clinical significance?
Histopathology. 2002 Mar;40(3):211-4. doi: 10.1046/j.1365-2559.2002.01327.x.
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Tc-99m sestamibi and In-111 DTPA octreotide uptake in breast carcinoma with neurendocrine differentiation.
Clin Nucl Med. 2000 Jun;25(6):482-3. doi: 10.1097/00003072-200006000-00023.
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Primary neuroendocrine tumor of the breast.
Med Oncol. 1997 Jun;14(2):121-3. doi: 10.1007/BF02990956.
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Carcinomas of the breast with endocrine differentiation: a review.
Virchows Arch. 1994;425(5):449-57. doi: 10.1007/BF00197547.

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