Haydock Maria Monica, Sigdel Saroj, Pacioles Toni
Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK.
Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
SAGE Open Med Case Rep. 2018 Oct 30;6:2050313X18809268. doi: 10.1177/2050313X18809268. eCollection 2018.
Since its emergence as a chemotherapy agent, gemcitabine has been associated with cutaneous adverse reactions. Rash is reported to be the most common cutaneous adverse effect. Other reported cutaneous reactions in the literature include bullous dermatosis, pseudocellulitis, subacute cutaneous lupus alopecia, and palmar-plantar erythrodysesthesia. Skin necrosis is a very rare adverse effect of this otherwise well-tolerated chemotherapeutic agent. In searching the literature, only one other case has been reported. In our report, we present a 74-year-old male with adenocarcinoma of the pancreas, status-post pancreaticoduodenectomy (Whipple procedure), who developed a rare case of skin necrosis of the lower leg 2 weeks after completing six cycles of monotherapy gemcitabine treatment.
自吉西他滨作为一种化疗药物出现以来，它一直与皮肤不良反应相关。据报道，皮疹是最常见的皮肤不良反应。文献中报道的其他皮肤反应包括大疱性皮肤病、假蜂窝织炎、亚急性皮肤型红斑狼疮脱发和手足红斑感觉异常。皮肤坏死是这种耐受性良好的化疗药物非常罕见的不良反应。在检索文献时，仅报道过另外一例。在我们的报告中，我们介绍了一名74岁的男性，患有胰腺腺癌，接受了胰十二指肠切除术（惠普尔手术），在完成六个周期的吉西他滨单药治疗后两周，出现了一例罕见的小腿皮肤坏死病例。
