Depart. of Fine Chem., SNUT (Seoul National Univ. of Sci. and Tech.), Seoul 01188, Republic of Korea.
Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea and Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Photochem Photobiol Sci. 2019 Jan 1;18(1):166-176. doi: 10.1039/c8pp00408k. Epub 2018 Nov 6.
A novel multiple target sensor, (E)-5-((4-(diethylamino)-2-hydroxybenzyldene)amino)-1H-imidazole-4-carboxamide (DHIC), was synthesized for fluorescence detection of Zn and S and colorimetric detection of Fe in aqueous media. DHIC can operate as a turn "on-off" sequential fluorescent sensor for Zn and S. Detection limits (1.59 μM and 8.03 μM) for Zn and S are below the WHO standards (76.0 μM and 14.7 μM). The DHIC-Zn complex could be reversibly reused with ethylenediaminetetraacetic acid. Importantly, DHIC could image sequentially Zn and S in living cells. Moreover, DHIC displayed a discriminatory color change from pale yellow to orange yellow to Fe. The detection limit of DHIC for Fe (0.73 μM and 1.11 μM) is far below the EPA drinking water standard (5.37 μM). The sensor DHIC could be applied to analyze Fe in real samples.
一种新型的多靶标传感器，（E）-5-（（4-（二乙氨基）-2-羟基苯亚甲基）氨基）-1H-咪唑-4-甲酰胺（DHIC），被合成用于荧光检测 Zn 和 S 以及比色检测 Fe 在水介质中。DHIC 可以作为 Zn 和 S 的顺序“开-关”荧光传感器。Zn 和 S 的检测限（1.59 μM 和 8.03 μM）低于世界卫生组织标准（76.0 μM 和 14.7 μM）。DHIC-Zn 配合物可以与乙二胺四乙酸可逆重复使用。重要的是，DHIC 可以在活细胞中顺序成像 Zn 和 S。此外，DHIC 对 Fe 表现出从浅黄色到橙黄色的有区别的颜色变化。DHIC 对 Fe 的检测限（0.73 μM 和 1.11 μM）远低于 EPA 饮用水标准（5.37 μM）。传感器 DHIC 可用于分析实际样品中的 Fe。
