Wahba Nashwa, Sayeeduddin Syed, Diaz-Abad Montserrat, Scharf Steven M
Sleep Disorders Center, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, 100 N. Greene Street, 2nd Floor, Baltimore, MD, 21201, USA.
Sleep Breath. 2019 Sep;23(3):729-734. doi: 10.1007/s11325-018-1747-y. Epub 2018 Nov 5.
Traditionally, evaluation of obstructive sleep apnea (OSA) has consisted of a diagnostic polysomnogram (PSG), followed by a continuous positive pressure (CPAP) titration. However, to reduce costs, many third-party payers mandate performance of split-night studies (SPL), combining diagnostic and CPAP titration testing. We ascertained the utility of performing SPL for diagnosis and treatment of OSA.
We reviewed the PSG records of 200 patients suspected of having OSA. Using both American Academy of Sleep Medicine (AASM) and Medicare (CMS) criteria for scoring, we calculated the sensitivity, specificity, positive (PPV), and negative predictive value (NPV) of the AHI in the first 2 h of sleep for predicting an overall AHI > 15.
For predicting an overall AHI > 15, the sensitivity, specificity, PPV, and NPV of an AHI (AASM criteria) > 40 in the first 2 h were respectively: 0.304, 1.000, 1.000, and 0.335. For an AHI > 20 in the first 2 h, the corresponding values were 0.770, 0.962, 0.983, and 0.595. Corresponding values using CMS criteria were 0.347, 1.0, 1.0, and 0.6 for AHI > 40, and 0.693, 0.99, 0.986, and 0.76 for AHI > 20, respectively.
For justification of CPAP (overall AHI > 15), the sensitivity is slightly lower when using an AHI > 40 vs AHI > 20, but the specificity and PPV are much higher. Using AHI > 20 as criteria for SPL as opposed to the guideline criteria of AHI > 40 may be more effective in obtaining CPAP for patients with moderate to severe OSA.
传统上,阻塞性睡眠呼吸暂停(OSA)的评估包括诊断性多导睡眠图(PSG),随后进行持续气道正压通气(CPAP)滴定。然而,为了降低成本,许多第三方支付方要求进行分夜研究(SPL),将诊断和CPAP滴定测试结合起来。我们确定了进行SPL用于OSA诊断和治疗的效用。
我们回顾了200例疑似患有OSA患者的PSG记录。使用美国睡眠医学学会(AASM)和医疗保险(CMS)的评分标准,我们计算了睡眠前2小时内呼吸暂停低通气指数(AHI)对于预测总体AHI>15的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)。
为了预测总体AHI>15,前2小时内AHI(AASM标准)>40的敏感性、特异性、PPV和NPV分别为:0.304、1.000、1.000和0.335。对于前2小时内AHI>20,相应的值分别为0.770、0.962、0.983和0.595。使用CMS标准时,AHI>40的相应值分别为0.347、1.0、1.0和0.6,AHI>20的相应值分别为0.693、0.99、0.986和0.76。
对于CPAP治疗的合理性(总体AHI>15),使用AHI>40与AHI>20相比,敏感性略低,但特异性和PPV更高。与AHI>40的指南标准相比,使用AHI>20作为SPL标准可能对中重度OSA患者获得CPAP治疗更有效。