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[肾母细胞瘤的遗传性。关于三例同胞病例]

[Hereditary nature of nephroblastoma. Apropos of a case of 3 siblings].

作者信息

Chaouachi B, Marrakchi Z, Ben Salah S, Aloulou T, Dhaoui R, Gharbi H A, Saied H

出版信息

Ann Urol (Paris). 1987;21(2):102-4.

PMID:3039905
Abstract

Three nephroblastomas, including one bilateral tumour, have been detected in three children belonging to the same family and born from a consanguinous marriage. The clinical and diagnostic particularities compared to non familial "sporadic" nephroblastomas are studied. The pathogenesis with the incidence of chromosomal anomalies, the diagnosis and the frequency of bilateral diseases along with the associated deformities and a non invasive therapeutic attitude are discussed.

摘要

在一个近亲结婚家庭出生的三个孩子中检测到三例肾母细胞瘤,其中一例为双侧肿瘤。研究了与非家族性“散发性”肾母细胞瘤相比的临床和诊断特点。讨论了伴有染色体异常发生率的发病机制、双侧疾病的诊断和频率以及相关畸形和非侵入性治疗态度。

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