细胞生物学：微粒体复合物在锥虫中的功能保守性、结构多样性以及惊人的趋同性。
Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes.
机构信息
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, B3H 4R2 Nova Scotia, Canada.
出版信息
Curr Biol. 2018 Nov 5;28(21):R1245-R1248. doi: 10.1016/j.cub.2018.09.057.
PMID:30399345
Abstract
The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation.
摘要
MICOS 复合物在真核生物中是保守的，但在包括动物和真菌在内的这个群体之外，人们对它知之甚少。一项新的研究发现，动基体门寄生虫的线粒体具有一种具有祖先和衍生亚基的不同 MICOS，但在嵴的发育和膜接触位点形成方面具有保守功能。
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