The influence of the dT.dG mispair on the activity of the human DNA(cytosine-5)methyltransferase.
作者信息
Baker D J, Hardy T A, Smith S S
出版信息
Biochem Biophys Res Commun. 1987 Jul 31;146(2):596-602. doi: 10.1016/0006-291x(87)90570-5.
PMID:3039984
Abstract
Synthetic oligodeoxynucleotides containing a dT.dG mispair at a centrally located d(pCG) dimer are methylated at a moderate rate by highly purified human DNA(cytosine-5)methyltransferase (E.C. 2.1.1.37). The presence of a mispaired dT in one strand induced the enzyme to preferentially methylate the opposite strand.
摘要
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Human DNA (cytosine-5)methyltransferase selectively methylates duplex DNA containing mispairs.人类DNA（胞嘧啶-5）甲基转移酶可选择性地使含有错配的双链DNA发生甲基化。
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