Lee Jiyeon, Kim Jihyeon, Shin Seong A, Park Soowon, Yoon Dong Hyun, Kim Hongrae, Kim Yu Kyeong, Moon Min Kyong, Koo Bo Kyung, Lee Jun-Young
Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.
College of Medicine, Seoul National University, Seoul 03080, Korea.
J Clin Med. 2018 Nov 4;7(11):413. doi: 10.3390/jcm7110413.
It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline.
We recruited 160 participants (78 with Alzheimer's disease and 82 without Alzheimer's disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline.
The volumes of 7 regions in the gray matter were negatively related to insulin resistance in Alzheimer's disease ( =0.032). Hierarchical MMR analysis indicated that insulin resistance did not directly affect the cognitive decline but moderated the cognitive decline through the decrease in gray matter volume in the key brain regions, i.e., inferior orbitofrontal gyrus (left), middle cingulate gyrus (right), hippocampus (right), and precuneus (right) ( < 0.05 in each case).
Insulin resistance appears to exacerbate the cognitive decline associated with several gray matter volume loss.
暴露于胰岛素抵抗是否会加速认知衰退存在争议。本研究旨在调查胰岛素抵抗与灰质体积减少之间的关联，以预测认知衰退。
我们招募了160名参与者（78名患有阿尔茨海默病，82名未患阿尔茨海默病）。评估了胰岛素抵抗、局部灰质体积和认知功能。使用分层调节多元回归（MMR）模型来确定胰岛素抵抗、大脑结构变化和认知衰退之间的任何关联。
阿尔茨海默病患者灰质中7个区域的体积与胰岛素抵抗呈负相关（=0.032）。分层MMR分析表明，胰岛素抵抗并不直接影响认知衰退，而是通过关键脑区（即眶额下回（左侧）、扣带回中部（右侧）、海马体（右侧）和楔前叶（右侧））灰质体积的减少来调节认知衰退（每种情况均<0.05）。
胰岛素抵抗似乎会加剧与多种灰质体积减少相关的认知衰退。
