Grześkowiak Tomasz, Zgoła-Grześkowiak Agnieszka, Rusińska-Roszak Danuta, Zaporowska-Stachowiak Iwona, Jeszka-Skowron Magdalena
Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Poznań, Poland.
Institute of Technology and Chemical Engineering, Poznan University of Technology, Poznań, Poland.
Eur J Mass Spectrom (Chichester). 2018 Dec;24(6):420-436. doi: 10.1177/1469066718812459. Epub 2018 Nov 6.
The results of research on selected drugs used in palliative care are presented, including fentanyl, tramadol, metoclopramide, hyoscine butylbromide, midazolam, haloperidol, levomepromazine and clonazepam. Interpretation of their ESI mass spectra obtained by the use of a triple quadrupole linear ion trap mass spectrometer is given. As a result, fragmentation pathways described in the literature are complemented and presented with more details. On their basis, transitions for quantitative analysis are selected and chromatographic conditions for the determination of the palliative care drugs are proposed as well. These results enable future studies on palliative care drugs in elderly patients including both their quantitation in body fluids and easier identification of their metabolites.
介绍了用于姑息治疗的选定药物的研究结果，包括芬太尼、曲马多、甲氧氯普胺、丁溴东莨菪碱、咪达唑仑、氟哌啶醇、左美丙嗪和氯硝西泮。给出了使用三重四极杆线性离子阱质谱仪获得的它们的电喷雾电离质谱图的解释。结果，对文献中描述的裂解途径进行了补充并更详细地呈现。在此基础上，选择了用于定量分析的跃迁，并提出了测定姑息治疗药物的色谱条件。这些结果有助于未来对老年患者姑息治疗药物的研究，包括其在体液中的定量分析以及更容易识别其代谢物。
