Komissarov I V, Serdiuk S E, Kharin N A
Biull Eksp Biol Med. 1987 Jul;104(7):61-3.
The experiments on the isolated guinea-pig ileum have shown that the contractions caused by low frequency transmural stimulation are decreased by adenosine, baclofen, clofelin and morphine. Theophylline is a competing antagonist of adenosine and a noncompeting antagonist of baclofen, clofelin and morphine. The effects of the latter are not altered by 1,3-dipropyl-8-phenylxanthine suppressing adenosine effects. It is concluded that presynaptic effects of baclofen, clofelin and morphine depend on cAMP level in cholinergic neurons of myenteric plexus.
对豚鼠离体回肠进行的实验表明，腺苷、巴氯芬、氯贝胆碱和吗啡可降低低频透壁刺激引起的收缩。茶碱是腺苷的竞争性拮抗剂，是巴氯芬、氯贝胆碱和吗啡的非竞争性拮抗剂。1,3 - 二丙基 - 8 - 苯基黄嘌呤抑制腺苷作用时，后三者的效应未改变。得出的结论是，巴氯芬、氯贝胆碱和吗啡的突触前效应取决于肌间神经丛胆碱能神经元中的环磷酸腺苷水平。
