[肽类的阿片样活性与皮肤伤口愈合]
[Opioid activity of peptides and wound healing of the skin].
作者信息
Vinogradov V A, Spevak S E, Iarygin K N, Korobov N V, Solov'eva A I
出版信息
Biull Eksp Biol Med. 1987 Jul;104(7):89-91.
The binding of dalargin, its four analogues and FK-33824, DADLE, met-enkephalin and morphine to peripheral mu- and delta-receptors and to brain receptors has been investigated in comparison with their influence on skin wound healing in rats. It has been shown that only substances with opiate activity, including morphine, stimulated wound healing. No correlation between wound healing effect of peptides and their binding to a definite receptor has been found. Naloxone inhibited wound healing and suppressed opiate peptide-mediated healing process. It is suggested that endogenous opiate peptides are involved in the maintenance of structural homeostasis.
研究了达拉argin、其四种类似物以及FK-33824、DADLE、甲硫氨酸脑啡肽和吗啡与外周μ-和δ-受体以及脑受体的结合情况，并与它们对大鼠皮肤伤口愈合的影响进行了比较。结果表明，只有具有阿片活性的物质，包括吗啡，能刺激伤口愈合。未发现肽的伤口愈合效果与其与特定受体的结合之间存在相关性。纳洛酮抑制伤口愈合并抑制阿片肽介导的愈合过程。提示内源性阿片肽参与维持结构稳态。
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