Ottosen P D, Nyengård J R, Jacobsen N O, Christensen S
Cell Tissue Res. 1987 Aug;249(2):311-5. doi: 10.1007/BF00215513.
Rats were given a lithium-containing diet (40 mmol/kg) to study the effect of lithium on the structure of collecting ducts from the inner stripe of the outer medulla. The results show that there is a significant increase in the volume density of collecting ducts already after one week on this diet. The volume density of both intercalated and principal cells increases, whereas the volume density of mitochondria in the cytoplasm increases in the intercalated cells only. The increased volume of both principal and intercalated cells seems to be part of a general hyperplasia and hyperactivity of the collecting duct, which may in some way be related to the effects of lithium on vasopressin-mediated mediated water transport. The specific changes in the intercalated cells may be a consequence of the effects of lithium on distal nephron potassium and hydrogen ion transport in the distal nephron.
给大鼠喂食含锂饮食（40毫摩尔/千克），以研究锂对外髓质内带集合管结构的影响。结果表明，在这种饮食下仅一周后，集合管的体积密度就显著增加。闰细胞和主细胞的体积密度均增加，而仅闰细胞胞质中线粒体的体积密度增加。主细胞和闰细胞体积的增加似乎是集合管普遍增生和功能亢进的一部分，这可能在某种程度上与锂对血管加压素介导的水转运的影响有关。闰细胞的特定变化可能是锂对远端肾单位钾和氢离子转运影响的结果。
