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常规双 J 管置入术用于活体相关供肾移植受者:它没有达到目的,但它是否达到了更好的目的?

Routine double-J stenting for live related donor kidney transplant recipients: It doesn't serve the purpose, but does it serve a better purpose?

机构信息

Department of Urology, P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, India.

Department of Nephrology, P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, India.

出版信息

Investig Clin Urol. 2018 Nov;59(6):410-415. doi: 10.4111/icu.2018.59.6.410. Epub 2018 Oct 22.

Abstract

PURPOSE

Despite meticulous techniques, surgical complications continue to be problematic in kidney transplant recipients. Role of routine stenting to reduce complications is controversial. In this study, we compare incidence of early urological complications, lymphoceles, urinary tract infections (UTI) and graft function; with or without double-J stenting.

MATERIALS AND METHODS

All patients who underwent live related donor renal transplantation from February 2014 to February 2016 were included. Transplants prior to February 2015 were without routine stenting; subsequent transplants were with routine stenting. Patients with neurogenic bladder, previously operated bladder and delayed or low urinary output were excluded. Follow-up was for at least three months. Descriptive statistics was performed for all parameters. Chi square test and Fisher's Exact test were used for qualitative variables. For quantitative variables, Mann-Whitney test was used to test median difference and independent samples t-test for mean difference. The p-value ≤0.05 was considered significant.

RESULTS

We analysed 74 patients (34 stented and 40 non-stented). There was no difference in the incidence of urinary leak, anastomotic obstruction, lymphoceles or UTI (p>0.4 for all comparisons). However, mean estimated glomerular filtration rate at sixth day, 14th day, one month and two months were 76.1 vs. 61.5 (p=0.025), 72.1 vs. 56.6 (p=0.005), 79.4 vs. 63.1 (p=0.002) and 82.0 vs. 63.3 (p=0.001) in the stented versus non-stented groups.

CONCLUSIONS

Placement of ureteral stent in renal transplant does not significantly affect the incidence of early urinary complications or UTI. However, graft function is significantly better in stented recipients, at least in the short term.

摘要

目的

尽管手术技术十分精细,肾移植受者仍会发生手术并发症。常规置管是否能降低并发症仍存在争议。本研究比较了带管与不带管患者早期发生泌尿道并发症、淋巴囊肿、尿路感染(UTI)和移植物功能的情况。

材料与方法

所有于 2014 年 2 月至 2016 年 2 月行亲属活体供肾移植的患者均纳入本研究。2015 年 2 月前的移植术不带常规置管,之后的移植术带常规置管。患有神经性膀胱、曾行膀胱手术及存在延迟或低尿排出量的患者被排除在外。随访时间至少为 3 个月。对所有参数进行描述性统计。定性变量采用卡方检验和 Fisher 确切检验,定量变量采用 Mann-Whitney 检验检验中位数差异,采用独立样本 t 检验检验均值差异。p 值≤0.05 为差异有统计学意义。

结果

共分析了 74 例患者(置管 34 例,非置管 40 例)。在尿漏、吻合口梗阻、淋巴囊肿或 UTI 的发生率方面,两组间无差异(所有比较 p 值均>0.4)。然而,第 6 天、第 14 天、第 1 个月及第 2 个月的平均估计肾小球滤过率分别为 76.1 vs. 61.5(p=0.025)、72.1 vs. 56.6(p=0.005)、79.4 vs. 63.1(p=0.002)和 82.0 vs. 63.3(p=0.001)。

结论

在肾移植中置管不会显著影响早期泌尿道并发症或 UTI 的发生率,但置管组移植物功能至少在短期内更好。

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