Dominguez J, Clase C M, Mahalati K, MacDonald A S, McAlister V C, Belitsky P, Kiberd B, Lawen J G
Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada.
Transplantation. 2000 Aug 27;70(4):597-601. doi: 10.1097/00007890-200008270-00011.
Whether routine ureteric stenting in low-urological-risk patients reduces the risk of urological complications in kidney transplantation is not established.
Eligible patients were recipients of single-organ renal transplants with normal lower urinary tracts. Patients were randomized intraoperatively to receive either routine stenting or stenting only in the event of technical difficulties with the anastomosis. All patients underwent Lich-Gregoire ureteroneocystostomy.
Between June 1994 and December 1997, 331 kidney transplants were performed at a single center, 305 patients were eligible, and 280 patients were enrolled and randomized. Donor and recipient age, sex, donor source, whether first or subsequent grafts, ureteric length, native renal disease, and immunosuppression were similar in each group. In the no-routine-stenting group 6 of 137 patients (4.4%) received stents after randomization for intraoperative events that in the surgeon's opinion required use of a stent. In an intention-to-treat analysis there was no difference between groups in the primary outcome cluster of obstruction or leak [routine stenting 5 of 143 (3.5%) vs. no routine stenting 9 of 137 (6.6%); P=0.23], or in either of these complications analyzed separately. All urological complications were successfully managed without major morbidity. Living donor organs and shorter ureteric length (after trimming) were univariate risk factors for leaks, although increasing donor age was associated with obstruction.
Routine ureteric stenting is unnecessary in kidney transplantation in patients at low risk for urological complications. Careful surgical technique with selective stenting of problematic anastomoses yields similar results.
低泌尿系统风险患者在肾移植中进行常规输尿管支架置入术是否能降低泌尿系统并发症的风险尚未明确。
符合条件的患者为下尿路正常的单器官肾移植受者。患者在术中随机分组,一组接受常规支架置入术,另一组仅在吻合技术出现困难时进行支架置入术。所有患者均接受利奇 - 格雷戈里输尿管膀胱吻合术。
1994年6月至1997年12月期间,在单一中心进行了331例肾移植手术,305例患者符合条件,280例患者被纳入并随机分组。每组的供体和受体年龄、性别、供体来源、是否为首次或再次移植、输尿管长度、原肾疾病以及免疫抑制情况相似。在非常规支架置入组中,137例患者中有6例(4.4%)在随机分组后因术中出现外科医生认为需要使用支架的情况而接受了支架置入。在意向性分析中,两组在梗阻或渗漏这一主要结局指标上无差异[常规支架置入组143例中有5例(3.5%),非常规支架置入组137例中有9例(6.6%);P = 0.23],单独分析这两种并发症时也无差异。所有泌尿系统并发症均成功处理,未出现严重并发症。活体供体器官和较短的输尿管长度(修剪后)是渗漏的单因素危险因素,尽管供体年龄增加与梗阻有关。
泌尿系统并发症风险低的患者在肾移植中无需常规输尿管支架置入术。采用精细的手术技术并对有问题的吻合口进行选择性支架置入可取得相似的结果。