Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences International Campus (TUMS-IC), Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Nutr Diet. 2019 Apr;76(2):192-198. doi: 10.1111/1747-0080.12482. Epub 2018 Nov 7.
Obesity is an emerging public health problem, with its incidence on the rise. An abnormal metabolic profile is a risk factor for developing obesity. Dietary factors play a central role in the regulation of inflammation and obesity. The aim of the present study was to determine the prevalence of metabolically healthy obese and metabolically unhealthy obese (MUO) phenotypes, and their association with dietary inflammatory index (DII) among obese Iranian people.
A cross-sectional study was conducted from July to October 2017 among 300 obese participants in southern Tehran. DII scores were computed based on the overall inflammatory properties of 32 dietary components using dietary intake assessed by food frequency questionnaire. MUO phenotype was defined as having three or more of these metabolic abnormalities: high blood glucose, high triglycerides, low high-density lipoprotein cholesterol, elevated blood pressure or abdominal obesity. The association was determined using logistic regression analysis.
The MUO phenotype (n = 176) was found in 63.5% of obese participants. Compared with participants in the first quartile, those in the fourth quartile of DII score (more pro-inflammatory diet) had higher odds of MUO phenotype (odds ratio, OR: 2.58 (95% CI: 1.19-5.59), P = 0.04), and there was a significant association between the continuous form of DII score and the odds of MUO phenotype (OR: 1.18 (95% CI: 1.01-1.37)) after adjusting for potential confounders.
Higher DII scores were positively associated with the MUO phenotype. A more pro-inflammatory diet is a potential risk factor for MUO phenotype.
肥胖是一个新出现的公共卫生问题，其发病率呈上升趋势。异常的代谢特征是肥胖发生的一个风险因素。饮食因素在炎症和肥胖的调节中起着核心作用。本研究旨在确定代谢健康肥胖和代谢不健康肥胖（MUO）表型在伊朗肥胖人群中的流行情况及其与饮食炎症指数（DII）的关系。
2017 年 7 月至 10 月，在德黑兰南部对 300 名肥胖参与者进行了一项横断面研究。根据膳食频率问卷评估的饮食摄入情况，基于 32 种饮食成分的整体炎症特性，计算 DII 评分。MUO 表型定义为存在三种或更多以下代谢异常：高血糖、高甘油三酯、低高密度脂蛋白胆固醇、血压升高或腹部肥胖。使用逻辑回归分析确定关联。
在肥胖参与者中，MUO 表型（n=176）占 63.5%。与 DII 评分第一四分位组的参与者相比，DII 评分第四四分位组（更促炎饮食）的 MUO 表型发生的可能性更高（比值比，OR：2.58（95%可信区间：1.19-5.59），P=0.04），且 DII 评分的连续形式与 MUO 表型的发生可能性之间存在显著关联（OR：1.18（95%可信区间：1.01-1.37）），调整了潜在混杂因素后。
较高的 DII 评分与 MUO 表型呈正相关。更促炎的饮食可能是 MUO 表型的一个潜在风险因素。
