Crum E D, Despommier D D, McGregor D D
Immunology. 1977 Dec;33(6):787-95.
Rats can be solidly immunized against Trichinella spiralis by a series of methyridine-terminated oral infections with T. spiralis larvae. Injections of thoracic duct lymphocytes (TDL) obtained from such animals can protect normal rats against a Trichinella challenge. The protective cells belong to two populations which differ with respect to their adherence to affinity columns prepared with rabbit antibody to rat F(ab')2. Immune lymphocytes in the column-adherent B cell fraction are inhibited by vinblastine, whereas those in the non-adherent, T cell fraction are resistant to this drug. The above observations suggest that acquired resistance to T. spiralis is mediated by two classes of lymphocytes: B cells which are delivered to the thoracic duct and hence to the blood while still in active cycle, and T cells which have a potentially long life-span and presumably belong to a pool of recirculating small lymphocytes.
通过一系列用旋毛虫幼虫进行的甲噻嘧啶终止的口服感染，大鼠可被牢固地免疫以抵抗旋毛虫。从这类动物获得的胸导管淋巴细胞（TDL）注射可保护正常大鼠免受旋毛虫攻击。保护性细胞属于两个群体，它们在对用兔抗大鼠F(ab')2制备的亲和柱的黏附方面有所不同。柱黏附性B细胞部分中的免疫淋巴细胞被长春碱抑制，而非黏附性T细胞部分中的淋巴细胞对该药物有抗性。上述观察结果表明，对旋毛虫的获得性抗性由两类淋巴细胞介导：仍处于活跃周期时被输送到胸导管并因此进入血液的B细胞，以及具有潜在长寿命且大概属于再循环小淋巴细胞池的T细胞。
