ZIK Plasmatis, Leibniz-Institute for Plasma Science and Technology, Felix-Hausdorff-Str. 2, D-17489 Greifswald, Germany.
Leibniz-Institute for Plasma Science and Technology, Felix-Hausdorff-Str. 2, D-17489 Greifswald, Germany.
Biol Chem. 2018 Dec 19;400(1):19-38. doi: 10.1515/hsz-2018-0242.
Reactive oxygen and nitrogen species deposited by cold physical plasma are proposed as predominant effectors in the interaction between discharge and biomedical application. Most reactive species found in plasma sources are known in biology for inter- and intracellular communication (redox signaling) and mammalian cells are equipped to interpret the plasma derived redox signal. As such, considerable effort has been put into the investigation of potential clinical applications and the underlying mechanism, with a special emphasis on conditions orchestrated significantly via redox signaling. Among these, immune system control in wound healing and cancer control stands out with promising in vitro and in vivo effects. From the fundamental point of view, further insight in the interaction of the plasma-derived species with biological systems is desired to (a) optimize treatment conditions, (b) identify new fields of application, (c) to improve plasma source design, and (d) to identify the trajectories of reactive species. Knowledge on the biochemical reactivity of non-thermal plasmas is compiled and discussed. While there is considerable knowledge on proteins, lipids and carbohydrates have not received the attention deserved. Nucleic acids have been profoundly investigated yet focusing on molecule functionality rather than chemistry. The data collected underline the efforts taken to understand the fundamentals of plasma medicine but also indicate 'no man's lands' waiting to be discovered.
冷等离子体沉积的活性氧和氮物种被认为是放电与生物医学应用相互作用的主要效应物。等离子体源中发现的大多数活性物质在生物学中已知用于细胞间和细胞内通讯（氧化还原信号），并且哺乳动物细胞能够解释等离子体衍生的氧化还原信号。因此，人们已经投入了相当大的努力来研究潜在的临床应用和潜在的机制，特别强调通过氧化还原信号显著协调的条件。在这些条件中，伤口愈合和癌症控制中的免疫系统控制引人注目，具有有前途的体外和体内效果。从根本的角度来看，希望进一步了解等离子体衍生物质与生物系统的相互作用，以（a）优化治疗条件，（b）确定新的应用领域，（c）改进等离子体源设计，以及（d）确定活性物质的轨迹。编译和讨论了关于非热等离子体的生化反应性的知识。虽然对蛋白质有相当多的了解，但脂质和碳水化合物并没有得到应有的重视。尽管已经对核酸进行了深入研究，但重点是分子功能而不是化学。收集的数据强调了为理解等离子体医学的基础而付出的努力，但也表明有待发现的“无人区”。
