Arjunan Krishna Priya, Sharma Virender K, Ptasinska Sylwia
Radiation Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA.
Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, 1266 TAMU, College Station, TX 77843, USA.
Int J Mol Sci. 2015 Jan 29;16(2):2971-3016. doi: 10.3390/ijms16022971.
Atmospheric Pressure Plasma (APP) is being used widely in a variety of biomedical applications. Extensive research in the field of plasma medicine has shown the induction of DNA damage by APP in a dose-dependent manner in both prokaryotic and eukaryotic systems. Recent evidence suggests that APP-induced DNA damage shows potential benefits in many applications, such as sterilization and cancer therapy. However, in several other applications, such as wound healing and dentistry, DNA damage can be detrimental. This review reports on the extensive investigations devoted to APP interactions with DNA, with an emphasis on the critical role of reactive species in plasma-induced damage to DNA. The review consists of three main sections dedicated to fundamental knowledge of the interactions of reactive oxygen species (ROS)/reactive nitrogen species (RNS) with DNA and its components, as well as the effects of APP on isolated and cellular DNA in prokaryotes and eukaryotes.
大气压等离子体（APP）正广泛应用于各种生物医学领域。等离子体医学领域的大量研究表明，在原核生物和真核生物系统中，APP均以剂量依赖的方式诱导DNA损伤。最近的证据表明，APP诱导的DNA损伤在许多应用中显示出潜在益处，如灭菌和癌症治疗。然而，在其他一些应用中，如伤口愈合和牙科领域，DNA损伤可能是有害的。本综述报道了关于APP与DNA相互作用的广泛研究，重点阐述了活性物种在等离子体诱导的DNA损伤中的关键作用。该综述由三个主要部分组成，分别致力于活性氧（ROS）/活性氮（RNS）与DNA及其组分相互作用的基础知识，以及APP对原核生物和真核生物中分离的DNA和细胞DNA的影响。
Zotero 插件
