三磷酸肌醇（IP3）的增加先于α-肾上腺素能受体诱导的心肌收缩力增加。
Increase in IP3 precedes alpha-adrenoceptor-induced increase in force of contraction in cardiac muscle.
作者信息
Schmitz W, Scholz H, Scholz J, Steinfath M
出版信息
Eur J Pharmacol. 1987 Aug 4;140(1):109-11. doi: 10.1016/0014-2999(87)90641-8.
PMID:3040445
Abstract
In electrically driven left auricles isolated from rat hearts the alpha 1-adrenoceptor agonist phenylephrine increased inositol trisphosphate (IP3) and force of contraction. The increase in IP3 preceded the increase in force of contraction, indicating that the alpha 1-adrenoceptor-mediated increase in IP3 and force of contraction may have been causally related.
摘要
在从大鼠心脏分离出的电驱动左心房中，α1 -肾上腺素能受体激动剂去氧肾上腺素增加了肌醇三磷酸（IP3）和收缩力。IP3的增加先于收缩力的增加，这表明α1 -肾上腺素能受体介导的IP3增加和收缩力增加可能存在因果关系。
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