Department of Pathology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Department of Oral and Maxillofacial Diseases, Head and Neck Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Acta Odontol Scand. 2019 Jan;77(1):82-87. doi: 10.1080/00016357.2018.1532530. Epub 2018 Nov 7.
This study aims to clarify demographic and clinical aspects of patients with ameloblastoma treated at a single Finnish institute during 1985-2016. Associations between predictor variables (gender and age) and outcome variables (location, tumour type, growth patterns and average tumour size) were sought. A retrospective cohort study was designed and implemented including 34 patients diagnosed with primary ameloblastoma and treated at the Helsinki University Central Hospital. Patient records were investigated, and tissue samples re-evaluated. The chi-square test was used on all categorized variables and -test for continuous ones. A value equal to or under .05 was considered significant. Males were slightly more predominant among the Finnish patients with ameloblastoma. Maxillary tumours were seen exclusively in male patients ( = .034). Additionally, these patients were older than patients with mandibular tumours ( = .007). A mixture in histological growth patterns was more common than originally anticipated. The study revealed a wide range of clinical signs and subjective symptoms, of which pain or other sensations were experienced most often. This study of 34 subjects shows that southern Finnish patients with ameloblastoma do not substantially differ from patients in similar study designs.
本研究旨在阐明 1985 年至 2016 年在芬兰一家医疗机构接受治疗的成釉细胞瘤患者的人口统计学和临床特征。探讨了预测变量(性别和年龄)与结局变量(位置、肿瘤类型、生长模式和平均肿瘤大小)之间的相关性。本研究采用回顾性队列设计,纳入了在赫尔辛基大学中心医院接受治疗的 34 名原发性成釉细胞瘤患者。调查了患者的病历,并重新评估了组织样本。对所有分类变量进行卡方检验,对连续变量进行 t 检验。P 值等于或小于.05 被认为具有统计学意义。芬兰成釉细胞瘤患者中男性略占优势。上颌肿瘤仅见于男性患者(P 值等于.034)。此外,这些患者比下颌肿瘤患者年龄更大(P 值等于.007)。组织学生长模式的混合比预期更为常见。本研究纳入了 34 名患者,结果显示,这些患者的临床表现和主观症状差异很大,其中疼痛或其他感觉最为常见。本研究纳入了 34 名患者,结果表明,来自芬兰南部的成釉细胞瘤患者与其他类似设计研究中的患者没有明显差异。