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恙虫病合并心肌炎和横纹肌溶解症 1 例报告。

A case report of scrub typhus complicated with myocarditis and rhabdomyolysis.

机构信息

Departments of Internal Medicine, College of Medicine, Chosun University, 588 Seosuk-dong, Dong-gu, Gwangju, 61453, Republic of Korea.

Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.

出版信息

BMC Infect Dis. 2018 Nov 7;18(1):551. doi: 10.1186/s12879-018-3458-1.

Abstract

BACKGROUND

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. Myocarditis and rhabdomyolysis are rare complications of scrub typhus.

CASE PRESENTATION

We report a case of scrub typhus, which was simultaneously complicated with myocarditis and rhabdomyolysis. A 54-year-old woman presented to our hospital with myalgia in the upper and lower limbs, oedema and a fever of 7 days' duration. We confirmed the diagnosis of scrub typhus complicated with myocarditis by pericardial fluid analysis and cardiac magnetic resonance imaging results. The pericardial fluid showed characteristics of an exudate, an elevated immunofluorescence assay (IFA) IgG titer of 1:2048 and a positive 16S rRNA qPCR result. We also diagnosed rhabdomyolysis by the patient's presenting symptoms, elevated muscle enzyme levels and bone scan results.

CONCLUSION

We report for the first time a case of scrub typhus complicated with both myocarditis and rhabdomyolysis, the causative agent of which was the Boryong genotype of O. tsutsugamushi.

摘要

背景

恙虫病是由恙虫东方体引起的一种人畜共患疾病,恙虫东方体是一种革兰阴性细胞内细菌。心肌炎和横纹肌溶解症是恙虫病的罕见并发症。

病例介绍

我们报告了一例恙虫病,同时并发心肌炎和横纹肌溶解症。一名 54 岁女性因四肢肌肉疼痛、水肿和发热 7 天就诊于我院。我们通过心包液分析和心脏磁共振成像结果确诊为并发心肌炎的恙虫病。心包液表现为渗出液特征,免疫荧光检测 IgG 滴度为 1:2048,16S rRNA qPCR 结果阳性。根据患者的症状、肌酶水平升高和骨扫描结果,我们还诊断为横纹肌溶解症。

结论

我们首次报告了一例同时并发心肌炎和横纹肌溶解症的恙虫病病例,其病原体为 Boryong 基因型的恙虫东方体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e7/6223005/f90cf0092d2e/12879_2018_3458_Fig1_HTML.jpg

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