[TWIK-related Acid Sensitive K Channels in the Regulation of Respiration and Sleep].

作者信息

Zhang De Lian, Shi Tian, Yao Xiao Guang, Li Nan Fang, Wen Lu

机构信息

Institute of Hypertension of Xinjiang Uygur Autonomous Region,Center for Hypertension of the People's Hospital of Xinjiang Uygur,Autonomous Region,Urumqi 830001,China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Oct 30;40(5):694-698. doi: 10.3881/j.issn.1000-503X.10208.

DOI:10.3881/j.issn.1000-503X.10208

PMID:30404704

Abstract

TWIK-related acid-sensitive K channel(TASK)is an important member of the two-pore-domain potassium channels family. It is widely expressed in the central nervous system and peripheral tissues and is extremely sensitive to hypoxia and pH changes in extracellular fluid. TASK participates in regulating the expression of respiratory center and the respiratory movement and also plays certain role in sleep regulation. This article reviews the recent advances in the roles of TASK in the regulation of respiration and sleep.

摘要