Tjelum Louise, Eiken Pia
Ugeskr Laeger. 2018 Nov 5;180(45).
Recent reports imply, that denosumab discontinuation may lead to an increased risk of multiple vertebral fractures. This is a case report about two postmenopausal women, both with previous fragility fractures, who presented multiple vertebral fractures after denosumab discontinuation. One of the women also had symptomatic hypoparathyroid hypercalcaemia, six months after denosumab was discontinued. We recommend, that denosumab treatment should not be stopped without considering an alternative treatment.
近期报告表明，停用狄诺塞麦可能会导致多发性椎体骨折风险增加。本文报告了两名绝经后女性的病例，她们既往均有脆性骨折史，在停用狄诺塞麦后均出现了多发性椎体骨折。其中一名女性在停用狄诺塞麦6个月后还出现了有症状的甲状旁腺功能减退性高钙血症。我们建议，在未考虑替代治疗的情况下，不应停用狄诺塞麦治疗。
