禽肉瘤病毒长末端重复序列增强子区域的甲基化会抑制转录。
Methylation of the enhancer region of avian sarcoma virus long terminal repeat suppresses transcription.
作者信息
Guntaka R V, Gowda S, Wagner H, Simon D
出版信息
FEBS Lett. 1987 Sep 14;221(2):332-6. doi: 10.1016/0014-5793(87)80951-1.
PMID:3040472
Abstract
The effect of methylation of an enhancer on transcription was studied. A 245 bp enhancer-containing a fragment of the LTR of the avian sarcoma virus was methylated in vitro and ligated back into a vector which lacked the upstream enhancer sequence. The transient expression in QT6 cells indicated that methylation of the enhancer-containing sequence severely reduced the extent of transcription.
摘要
研究了增强子甲基化对转录的影响。一个含有禽肉瘤病毒长末端重复序列片段的245 bp增强子在体外进行甲基化，然后重新连接到一个缺乏上游增强子序列的载体中。QT6细胞中的瞬时表达表明，含增强子序列的甲基化严重降低了转录程度。
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