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Targeting myeloid cells to prevent recurrent stroke in general population: the lesson of hydroxyurea in myeloproliferative neoplasms.

作者信息

Barbui Tiziano, Finazzi Guido, Vannucchi Alessandro M, De Stefano Valerio

机构信息

FROM Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy.

Hematology Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy.

出版信息

Blood Cancer J. 2018 Nov 7;8(11):103. doi: 10.1038/s41408-018-0143-y.

DOI:10.1038/s41408-018-0143-y
PMID:30405115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6221886/
Abstract
摘要

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Targeting myeloid cells to prevent recurrent stroke in general population: the lesson of hydroxyurea in myeloproliferative neoplasms.针对普通人群中的髓样细胞以预防复发性中风：骨髓增殖性肿瘤中羟基脲的经验教训。
Blood Cancer J. 2018 Nov 7;8(11):103. doi: 10.1038/s41408-018-0143-y.
2
Hydroxyurea prevents arterial and late venous thrombotic recurrences in patients with myeloproliferative neoplasms but fails in the splanchnic venous district. Pooled analysis of 1500 cases.羟基脲可预防骨髓增殖性肿瘤患者的动脉和晚期静脉血栓复发，但在脾静脉区无效。1500 例的汇总分析。
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3
Successful Decitabine Treatment in Unfit, Elderly Patients with Acute Myeloid Leukemia following Chronic Myeloproliferative Neoplasm.地西他滨成功治疗不适合化疗的慢性骨髓增殖性肿瘤后急性髓系白血病老年患者
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4
[Ulcers following therapy with hydroxyurea. Three case reports and review of the literature].[羟基脲治疗后的溃疡。三例病例报告及文献复习]
Hautarzt. 2010 Jul;61(7):598-602. doi: 10.1007/s00105-009-1794-1.
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Gangrene of the fingers secondary to myeloproliferative disease.骨髓增殖性疾病继发手指坏疽
Postgrad Med. 1991 Jul;90(1):115-8. doi: 10.1080/00325481.1991.11700984.
6
[Hypereosinophilic syndrome: a new case of myeloproliferative type].
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7
Prevention of recurrent thrombosis following liver transplantation for Budd-Chiari syndrome associated with myeloproliferative disorders: treatment with hydroxyurea and aspirin.布加综合征合并骨髓增殖性疾病肝移植术后复发性血栓形成的预防：羟基脲和阿司匹林治疗
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[Clinical pharmacology of hydroxyurea].[羟基脲的临床药理学]
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Treatment of myeloproliferative syndrome with hydroxyurea.用羟基脲治疗骨髓增殖综合征。
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Primary Arterial Hypertension and Drug-Induced Hypertension in Philadelphia-Negative Classical Myeloproliferative Neoplasms: A Systematic Review.费城阴性经典型骨髓增殖性肿瘤中的原发性动脉高血压和药物性高血压：一项系统评价
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本文引用的文献

1
Myeloid cell contributions to cardiovascular health and disease.骨髓细胞对心血管健康和疾病的贡献。
Nat Med. 2018 Jun;24(6):711-720. doi: 10.1038/s41591-018-0064-0. Epub 2018 Jun 4.
2
Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke.短暂性脑缺血发作或小面积缺血性脑卒中后 5 年内的脑卒中风险。
N Engl J Med. 2018 Jun 7;378(23):2182-2190. doi: 10.1056/NEJMoa1802712. Epub 2018 May 16.
3
Benefit-risk profile of cytoreductive drugs along with antiplatelet and antithrombotic therapy after transient ischemic attack or ischemic stroke in myeloproliferative neoplasms.骨髓增殖性肿瘤患者短暂性脑缺血发作或缺血性脑卒中后细胞毒性药物与抗血小板和抗血栓治疗的获益-风险特征。
Blood Cancer J. 2018 Feb 28;8(3):25. doi: 10.1038/s41408-018-0048-9.
4
Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study.隐源性短暂性脑缺血发作和缺血性卒中的发病率、结局、危险因素及长期预后：一项基于人群的研究。
Lancet Neurol. 2015 Sep;14(9):903-913. doi: 10.1016/S1474-4422(15)00132-5. Epub 2015 Jul 27.
5
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.镰状细胞病的管理：专家小组成员 2014 年循证报告的总结。
JAMA. 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517.
6
Myeloproliferative neoplasms and thrombosis.骨髓增殖性肿瘤与血栓。
Blood. 2013 Sep 26;122(13):2176-84. doi: 10.1182/blood-2013-03-460154. Epub 2013 Jul 3.
7
Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms.骨髓增殖性肿瘤向急性髓系白血病和骨髓增生异常综合征转化的治疗相关危险因素。
J Clin Oncol. 2011 Jun 10;29(17):2410-5. doi: 10.1200/JCO.2011.34.7542. Epub 2011 May 2.
8
Systematic review: Hydroxyurea for the treatment of adults with sickle cell disease.系统评价：羟基脲用于治疗成人镰状细胞病
Ann Intern Med. 2008 Jun 17;148(12):939-55. doi: 10.7326/0003-4819-148-12-200806170-00221. Epub 2008 May 5.
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Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia.羟基脲与阿那格雷治疗高危原发性血小板增多症的比较。
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Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?白细胞增多与缺血性血管疾病的发病率和死亡率：是时候进行干预了吗？
Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):658-70. doi: 10.1161/01.ATV.0000156877.94472.a5. Epub 2005 Jan 20.