Clinical and Laboratory Features Associated with Acute Kidney Injury in Severe Malaria.

INTRODUCTION

Critically ill severe malaria constitutes one of the major hospital admissions in Indian setting. Clinical studies identifying the factors associated with acute kidney injury (AKI) in malaria are lacking. This study aimed to identify these factors.

METHODS

This prospective observational study was conducted in a tertiary care center of North India. All adult patients with severe malaria were studied during 2012-2014.

RESULTS

The study included 79 patients and AKI was observed in 36 patients. Of these 79 patients, 52.7% were positive and 47.2% were positive. In AKI patients, thrombocytopenia and jaundice were the most common other complications seen. Among malarial patients, 17 (36%) patients had AKI. Features associated with AKI among patients admitted with malaria were as follows: tachycardia (adjusted relative risk [RR]: 3.9; 95% confidence interval [CI]: 1.1-13.7), direct hyperbilirubinemia (adjusted RR: 4.7; 95% CI: 1.4-15.2), anemia (adjusted RR: 6; 95% CI: 1.7-22.4), and sepsis (adjusted RR: 3.3; 95% CI: 1.1-13.7). The presence of tachycardia, acidosis, cerebral malaria, acute respiratory distress syndrome/acute lung injury, hypotensive shock, and poor Glasgow Coma Scale were associated with higher mortality in patients with AKI. Patients who required mechanical ventilation and/or vasopressor support had higher mortality.

CONCLUSION

is an important cause of severe malaria with AKI in our setting. Various other clinical features are associated with AKI and related mortality.