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运用紧凑协同进化算法进行生物医学本体匹配。

Using Compact Coevolutionary Algorithm for Matching Biomedical Ontologies.

机构信息

College of Information Science and Engineering, Fujian University of Technology, Fuzhou 350118, China.

College of IOT Engineering, Hohai University, Nanjing 213022, China.

出版信息

Comput Intell Neurosci. 2018 Oct 8;2018:2309587. doi: 10.1155/2018/2309587. eCollection 2018.

DOI:10.1155/2018/2309587
PMID:30405706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6199880/
Abstract

Over the recent years, ontologies are widely used in various domains such as medical records annotation, medical knowledge representation and sharing, clinical guideline management, and medical decision-making. To implement the cooperation between intelligent applications based on biomedical ontologies, it is crucial to establish correspondences between the heterogeneous biomedical concepts in different ontologies, which is so-called biomedical ontology matching. Although Evolutionary algorithms (EAs) are one of the state-of-the-art methodologies to match the heterogeneous ontologies, huge memory consumption, long runtime, and the bias improvement of the solutions hamper them from efficiently matching biomedical ontologies. To overcome these shortcomings, we propose a compact CoEvolutionary Algorithm to efficiently match the biomedical ontologies. Particularly, a compact EA with local search strategy is able to save the memory consumption and runtime, and three subswarms with different optimal objectives can help one another to avoid the solution's bias improvement. In the experiment, two famous testing cases provided by Ontology Alignment Evaluation Initiative (OAEI 2017), i.e. anatomy track and large biomed track, are utilized to test our approach's performance. The experimental results show the effectiveness of our proposal.

摘要

近年来,本体在医学记录注释、医学知识表示和共享、临床指南管理和医学决策等各个领域得到了广泛应用。为了实现基于生物医学本体的智能应用之间的合作,建立不同本体中异构生物医学概念之间的对应关系至关重要,这就是所谓的生物医学本体匹配。虽然进化算法 (EA) 是匹配异构本体的最先进方法之一,但巨大的内存消耗、长时间运行和解决方案的偏差改进阻碍了它们有效地匹配生物医学本体。为了克服这些缺点,我们提出了一种紧凑的协同进化算法来有效地匹配生物医学本体。特别是,具有局部搜索策略的紧凑 EA 能够节省内存消耗和运行时间,并且具有三个不同最优目标的子群能够相互帮助避免解决方案的偏差改进。在实验中,利用 Ontology Alignment Evaluation Initiative (OAEI 2017) 提供的两个著名测试案例,即解剖学轨道和大型生物医学轨道,来测试我们方法的性能。实验结果表明了我们方案的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc0/6199880/e5dd4a44b1c7/CIN2018-2309587.alg.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc0/6199880/9c6c82078887/CIN2018-2309587.alg.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc0/6199880/e5dd4a44b1c7/CIN2018-2309587.alg.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc0/6199880/9c6c82078887/CIN2018-2309587.alg.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc0/6199880/e5dd4a44b1c7/CIN2018-2309587.alg.002.jpg

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本文引用的文献

1
BioAnnote: a software platform for annotating biomedical documents with application in medical learning environments.BioAnnote:一个用于为生物医学文献加注释的软件平台,适用于医学学习环境。
Comput Methods Programs Biomed. 2013 Jul;111(1):139-47. doi: 10.1016/j.cmpb.2013.03.007. Epub 2013 Apr 4.
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Semantic patient information aggregation and medicinal decision support.语义患者信息聚合和药物决策支持。
Comput Methods Programs Biomed. 2012 Nov;108(2):724-35. doi: 10.1016/j.cmpb.2012.04.002. Epub 2012 May 27.
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Ontology-driven execution of clinical guidelines.
基于本体的临床指南执行。
Comput Methods Programs Biomed. 2012 Aug;107(2):122-39. doi: 10.1016/j.cmpb.2011.06.006. Epub 2011 Jul 14.
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A reference ontology for biomedical informatics: the Foundational Model of Anatomy.生物医学信息学的参考本体:解剖学基础模型。
J Biomed Inform. 2003 Dec;36(6):478-500. doi: 10.1016/j.jbi.2003.11.007.
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The Unified Medical Language System (UMLS): integrating biomedical terminology.统一医学语言系统(UMLS):整合生物医学术语。
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