Sun Xinjun, Liu Xiang, Lu Nan, Yao Shulan, Xu Xiguang, Niu Lili
Department of Dermatology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.
Oncol Lett. 2018 Nov;16(5):6561-6565. doi: 10.3892/ol.2018.9493. Epub 2018 Sep 24.
Short-term curative effect and safety of propranolol combined with laser in the treatment of infantile hemangiomas was studied, so as to provide reference for clinical treatment. A total of 100 cases of infantile hemangiomas admitted to the Affiliated Hospital of Jining Medical University from October 2014 to June 2016 were selected into this study. According to the random number table method, they were divided into the control group and the observation group, with 50 cases in each group. The infant patients in the control group were treated with laser alone, and the infant patients in the observation group were treated with propranolol combined with laser. The healing time, the number of times of laser therapy, the short-term curative effect, the changes in serum inflammatory factors before and after treatment and the incidence of adverse reactions were compared between the two groups of infant patients. The healing time and the times of laser therapy of the infant patients in the observation group were less than those of the infant patients in the control group, and the differences were statistically significant (p<0.05). The short-term curative effect of the observation group (98%) was higher than that of the control group (82%), and the difference was statistically significant (p<0.05). The levels of serum inflammatory factors interleukin (IL)-2, IL-6 and IL-10 in the two groups of infant patients after treatment were lower than those before treatment, and the levels in the observation group were lower than those in the control group, and the differences were statistically significant (p<0.05). Propranolol combined with laser in the treatment of infantile hemangiomas has remarkable short-term curative effects. It can effectively reduce the levels of inflammatory factors, shorten the healing time and reduce the number of times of laser therapy. It is safe and worthy of clinical promotion.
研究普萘洛尔联合激光治疗婴幼儿血管瘤的短期疗效及安全性，为临床治疗提供参考。选取2014年10月至2016年6月济宁医学院附属医院收治的100例婴幼儿血管瘤患者纳入本研究。根据随机数字表法，将其分为对照组和观察组，每组50例。对照组婴幼儿患者单纯采用激光治疗，观察组婴幼儿患者采用普萘洛尔联合激光治疗。比较两组婴幼儿患者的愈合时间、激光治疗次数、短期疗效、治疗前后血清炎症因子变化及不良反应发生率。观察组婴幼儿患者的愈合时间和激光治疗次数少于对照组，差异有统计学意义（p<0.05）。观察组的短期疗效（98%）高于对照组（82%），差异有统计学意义（p<0.05）。两组婴幼儿患者治疗后血清炎症因子白细胞介素（IL）-2、IL-6和IL-10水平均低于治疗前，且观察组低于对照组，差异有统计学意义（p<0.05）。普萘洛尔联合激光治疗婴幼儿血管瘤具有显著的短期疗效。可有效降低炎症因子水平，缩短愈合时间，减少激光治疗次数。安全可靠，值得临床推广。
