Selmin Alessia, Foltran Francesca, Chiarelli Silvia, Ciullo Rosaria, Gregori Dario
Department for Women and Neonatal Care, Abano Terme General Hospital, Abano, PD, Italy.
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy.
Pathol Res Pract. 2014 Sep;210(9):548-53. doi: 10.1016/j.prp.2014.04.007. Epub 2014 Apr 23.
This study aimed to verify whether the infantile hemangioma (IH) incidence in children whose placentas showed a chorangioma is higher than in the general population, thus addressing the hypothesized relationship between chorangioma and IH.
All chorangioma diagnoses by the 1st Service of Pathology, University of Padova in 2004-2010, based on the analysis of placentas sent by the Department of Gynecological Sciences and Human Reproduction (University of Padova), were identified. Demographic, anamnestic and clinical data were collected from the mothers and newborns; mothers and pediatricians were interviewed by telephone within 1 year after birth to verify if any IH appeared. The incidence rates of IH and other adverse events (IUGR, preterm delivery, cesarean section, stillbirth) were compared with national and regional data, when available, or with estimates from the scientific literature.
Thirty-eight chorangioma diagnoses were found. Of 33 infants born with a placenta affected by chorangioma, 18 infants had IH. The IH incidence recorded in our series (55%) was significantly higher than that recorded in national and regional surveys and in the scientific literature. Similar findings have been observed for the incidence of stillbirth, preterm birth and low birth weight incidence.
The IH incidence observed in our series appears to be significantly higher than that recorded among the general population, suggesting that an association between placental chorangioma and IH could exist which should be further verified in prospective studies.
本研究旨在验证胎盘出现绒毛膜血管瘤的儿童患婴儿血管瘤（IH）的发生率是否高于普通人群，从而探讨绒毛膜血管瘤与IH之间的假设关系。
通过对帕多瓦大学第一病理科2004 - 2010年基于妇科科学与人类生殖系（帕多瓦大学）送检胎盘分析得出的所有绒毛膜血管瘤诊断病例进行识别。收集母亲和新生儿的人口统计学、既往史及临床数据；在出生后1年内通过电话访谈母亲和儿科医生，以核实是否出现任何IH。将IH及其他不良事件（胎儿生长受限、早产、剖宫产、死产）的发生率与可获取的国家和地区数据或科学文献中的估计值进行比较。
共发现38例绒毛膜血管瘤诊断病例。在33例出生时胎盘患有绒毛膜血管瘤的婴儿中，18例婴儿患有IH。我们系列研究中记录的IH发生率（55%）显著高于国家和地区调查以及科学文献中记录的发生率。死产、早产和低出生体重发生率也观察到类似结果。
我们系列研究中观察到的IH发生率似乎显著高于普通人群，这表明胎盘绒毛膜血管瘤与IH之间可能存在关联，应在前瞻性研究中进一步验证。
