Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Dermatology 1 Department, Colentina Clinical Hospital, 020125 Bucharest, Romania.
J Immunol Res. 2018 Oct 14;2018:7169081. doi: 10.1155/2018/7169081. eCollection 2018.
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. Initially regarded as a tumor suppressor as its expression shows considerable downregulation within the epithelia in the early phases of many solid cancers, CEACAM1 has been linked lately to the progression of malignancy and metastatic spread as various papers point to its role in tumor progression, angiogenesis, and invasion. We reviewed the literature and discussed the various expression patterns of CEACAM1 in different types of tumors, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis. The importance of understanding the role of CEACAM1 in cell transformation stands not only in this adhesion molecule's value as a prognostic factor but also in its promising premise as a potential new molecular target that could be exploited as a specific cancer therapy.
癌胚抗原相关细胞黏附分子 1（CEACAM1）是一种糖蛋白，属于癌胚抗原（CEA）家族，在多种细胞上表达，通过其可变剪接和产生各种异构体，在炎症中发挥复杂的调节和失调作用。CEACAM1 最初被认为是一种肿瘤抑制因子，因为它在许多实体瘤的上皮早期阶段表达明显下调，但最近的一些研究表明，CEACAM1 与恶性肿瘤的进展和转移扩散有关，因为各种研究表明它在肿瘤进展、血管生成和侵袭中发挥作用。我们查阅了文献，讨论了 CEACAM1 在不同类型肿瘤中的各种表达模式，描述了它的结构和一般生物学功能，并强调了将该分子与不良预后联系起来的最重要发现。理解 CEACAM1 在细胞转化中的作用不仅在于该黏附分子作为预后因素的价值，而且还在于其作为一种潜在的新分子靶点的有前途的前提，可作为一种特定的癌症治疗方法加以利用。
