Rudmann Daniel G
1 Charles River Laboratories, Ashland, Ohio, USA.
Toxicol Pathol. 2019 Jan;47(1):4-10. doi: 10.1177/0192623318809065. Epub 2018 Nov 8.
Microphysiological systems (MPS), commonly known as organs-on-chips, are a rapidly advancing technology that promises to impact many areas of medical and toxicological pathology. In this minireview, the history of MPS and its potential utility in safety assessment are described with the toxicologic pathologist in mind. Several MPS development focus areas are defined, and recent progress in the area is highlighted. MPS will likely become an important tool for the toxicologic pathologist as part of our role in the safety assessment process within the pharmaceutical, biotechnology, medical device, and cosmetic and agrichemical industries.
微生理系统（MPS），通常被称为芯片器官，是一项迅速发展的技术，有望对医学和毒理病理学的许多领域产生影响。在这篇小型综述中，我们从毒理病理学家的角度描述了MPS的历史及其在安全性评估中的潜在用途。定义了几个MPS的发展重点领域，并强调了该领域的最新进展。作为我们在制药、生物技术、医疗设备、化妆品和农业化学工业安全性评估过程中所扮演角色的一部分，MPS可能会成为毒理病理学家的一项重要工具。
