Low Lucie A, Tagle Danilo A
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
Exp Biol Med (Maywood). 2017 Oct;242(16):1573-1578. doi: 10.1177/1535370217700523. Epub 2017 Mar 26.
The National Institutes of Health Microphysiological Systems (MPS) program, led by the National Center for Advancing Translational Sciences, is part of a joint effort on MPS development with the Defense Advanced Research Projects Agency and with regulatory guidance from FDA, is now in its final year of funding. The program has produced many tangible outcomes in tissue chip development in terms of stem cell differentiation, microfluidic engineering, platform development, and single and multi-organ systems-and continues to help facilitate the acceptance and use of tissue chips by the wider community. As the first iteration of the program draws to a close, this Commentary will highlight some of the goals met, and lay out some of the challenges uncovered that will remain to be addressed as the field progresses. The future of the program will also be outlined. Impact statement This work is important to the field as it outlines the progress and challenges faced by the NIH Microphysiological Systems program to date, and the future of the program. This is useful information for the field to be aware of, both for current program stakeholders and future awardees and partners.
由美国国立推进转化科学中心牵头的美国国立卫生研究院微生理系统（MPS）项目，是与美国国防高级研究计划局共同开展MPS研发工作的一部分，并在美国食品药品监督管理局的监管指导下进行，目前已进入最后一年的资助阶段。该项目在组织芯片开发方面取得了许多切实成果，涵盖干细胞分化、微流控工程、平台开发以及单器官和多器官系统等领域，并持续助力推动更广泛的群体接受和使用组织芯片。随着该项目的首轮实施接近尾声，本评论将重点介绍已达成的一些目标，并阐述在该领域发展过程中发现的一些仍有待解决的挑战。同时，还将概述该项目的未来发展方向。影响声明 这项工作对该领域具有重要意义，因为它概述了美国国立卫生研究院微生理系统项目迄今为止所取得的进展和面临的挑战，以及该项目的未来发展方向。这对于该领域的相关人员，无论是当前项目的利益相关者，还是未来的受奖者和合作伙伴来说，都是有用的信息。
