Diezel W, Guenther W, Meffert H, Soennichsen N
J Invest Dermatol. 1978 Jan;70(1):33-7. doi: 10.1111/1523-1747.ep12543447.
In the acute phase of systemic lupus erythematosus the serum contains factors, with molecular weights ranging from 780,000 daltons to 1.5 million daltons, which induce blast transformation of autologous lymphocytes. In addition to the high-molecular weight components, low-molecular weight factors (75,000 and 160,000 daltons) which also induce an increase in lymphocytic transformation have also been demonstrated. In contrast to the high-molecular weight components the low-molecular factors stimulate the transformation of autologous and homologous lymphocytes. During transformation, lysis of autologous target fibroblasts occurs. The low-molecular weight mitogenic components remain stable after 30 min at 56 degrees C. The significance of such mediators for the pathogenesis of systemic lupus erythematosus is discussed.
在系统性红斑狼疮的急性期，血清中含有分子量从780,000道尔顿到150万道尔顿不等的因子，这些因子可诱导自体淋巴细胞的母细胞转化。除了高分子量成分外，还证实了低分子量因子（75,000和160,000道尔顿）也能诱导淋巴细胞转化增加。与高分子量成分不同，低分子量因子可刺激自体和同源淋巴细胞的转化。在转化过程中，自体靶成纤维细胞会发生裂解。低分子量促有丝分裂成分在56℃下30分钟后仍保持稳定。文中讨论了此类介质在系统性红斑狼疮发病机制中的意义。
