由氢气催化生成亲核氢化物并进行化学选择性转移
Catalytic Generation and Chemoselective Transfer of Nucleophilic Hydrides from Dihydrogen.
作者信息
Pape Felix, Brechmann Lea T, Teichert Johannes F
机构信息
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623, Berlin, Germany.
出版信息
Chemistry. 2019 Jan 18;25(4):985-988. doi: 10.1002/chem.201805530. Epub 2018 Dec 13.
Copper(I)-N-heterocyclic-carbene (NHC) complexes enabled the catalytic generation of nucleophilic hydrides from dihydrogen (H ) and their subsequent transfer to allylic chlorides. The highly chemoselective catalyst displayed no concomitant hydrogenation reactivity; in fact, the terminal double bond formed in the hydride transfer remained intact. Switching to deuterium gas (D ) allowed for regioselective monodeuteration with excellent isotope incorporation.
铜（I）-N-杂环卡宾（NHC）配合物能够催化由氢气（H₂）生成亲核氢化物，并随后将其转移至烯丙基氯上。这种具有高度化学选择性的催化剂没有伴随氢化反应活性；事实上，在氢化物转移过程中形成的末端双键保持完整。改用氘气（D₂）可实现区域选择性单氘代，且具有优异的同位素掺入率。
Zotero 插件