a Clinic of Paediatric Oncology and Haematology, Faculty of Medicine , University of Rzeszow , Rzeszow , Poland.
b Department of Paediatric Bone Marrow Transplantation, Oncology and Hematology , Wroclaw Medical University , Wroclaw , Poland.
Nutr Cancer. 2019;71(4):701-707. doi: 10.1080/01635581.2018.1516792. Epub 2018 Nov 8.
The incidence of treatment related mortality in children with acute lymphoblastic leukemia (ALL) is reported to be between 2% and 4% with infections being the leading cause.
To establish a relationship between body mass index at diagnosis (BMI 0), after protocol I therapy completion (BMI I) and the incidence rate ratio (IRR) of infectious/febrile episodes in children with ALL intermediate risk.
Thirty one consecutive patients (2-18 years old, with a male to female ratio of 19/12) with newly diagnosed ALL that were treated uniformly according to ALL IC 2009 protocol were included in this analysis.
A BMI decrease of at least 5% during protocol I therapy and BMI 1 under 15th percentile score corresponds significantly with higher IRR (with P-values 0.04 and 0.006 respectively) during the whole intensive therapy.
Some relationships between BMI reduction and higher IRR in ALL patients were found, but their significance is limited by the size of the group analyzed.
确定初诊时（BMI0）、完成方案 I 治疗后（BMI I）的体重指数与中危急性淋巴细胞白血病（ALL）患儿感染/发热发生率比值（IRR）之间的关系。
共纳入 31 例初诊 ALL 患儿（2-18 岁，男/女 19/12），均按 ALL IC 2009 方案进行治疗。
方案 I 治疗期间 BMI 至少下降 5%，且 BMI I 低于第 15 百分位评分，与整个强化治疗期间的高 IRR 显著相关（P 值分别为 0.04 和 0.006）。
发现 BMI 降低与 ALL 患儿高 IRR 之间存在一定关系，但因分析组例数有限，其意义受到限制。
