原发性中枢神经系统淋巴瘤患者液体活检中游离DNA上MYD88 p.(L265P)的检测 - Suppr

MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma.

作者信息

Hiemcke-Jiwa Laura S, Leguit Roos J, Snijders Tom J, Bromberg Jacoline E C, Nierkens Stefan, Jiwa N Mehdi, Minnema Monique C, Huibers Manon M H

机构信息

Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, the Netherlands.

出版信息

Br J Haematol. 2019 Jun;185(5):974-977. doi: 10.1111/bjh.15674. Epub 2018 Nov 8.

DOI:10.1111/bjh.15674

PMID:30408153

Abstract

摘要

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MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma.原发性中枢神经系统淋巴瘤患者液体活检中游离DNA上MYD88 p.(L265P)的检测

Br J Haematol. 2019 Jun;185(5):974-977. doi: 10.1111/bjh.15674. Epub 2018 Nov 8.

Liquid biopsy of cerebrospinal fluid for MYD88 L265P mutation is useful for diagnosis of central nervous system lymphoma.对脑脊液进行液体活检，检测 MYD88 L265P 突变，有助于中枢神经系统淋巴瘤的诊断。

Cancer Sci. 2021 Nov;112(11):4702-4710. doi: 10.1111/cas.15133. Epub 2021 Sep 27.

Analysis of Driver Mutational Hot Spots in Blood-Derived Cell-Free DNA of Patients with Primary Central Nervous System Lymphoma Obtained before Intracerebral Biopsy.原发性中枢神经系统淋巴瘤患者脑内活检前血游离 DNA 中驱动基因突变热点分析。

J Mol Diagn. 2020 Oct;22(10):1300-1307. doi: 10.1016/j.jmoldx.2020.07.002. Epub 2020 Aug 1.

The use of droplet digital PCR in liquid biopsies: A highly sensitive technique for MYD88 p.(L265P) detection in cerebrospinal fluid.液滴数字PCR在液体活检中的应用：一种用于检测脑脊液中MYD88 p.(L265P)的高灵敏度技术。

Hematol Oncol. 2018 Apr;36(2):429-435. doi: 10.1002/hon.2489. Epub 2017 Dec 6.

Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma.快速检测 MYD88 L265P 突变，用于原发性中枢神经系统淋巴瘤的术前和术中诊断。

Cancer Sci. 2023 Jun;114(6):2544-2551. doi: 10.1111/cas.15762. Epub 2023 Mar 1.

MYD88 L265P mutation and interleukin-10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study.MYD88 L265P 突变和脑脊液中白细胞介素-10 的检测是原发性中枢神经系统淋巴瘤患者具有高度特异性的鉴别标志物：一项前瞻性研究的结果。

Br J Haematol. 2021 May;193(3):497-505. doi: 10.1111/bjh.17357. Epub 2021 Feb 23.

Liquid biopsy for CNS lymphoma: CSF exosomes and CSF exosomal miR-15a, miR-21, miR-155, miR-210, and miR-19b are promising biomarkers for diagnosis.液体活检在中枢神经系统淋巴瘤中的应用：脑脊液外泌体和脑脊液外泌体 miR-15a、miR-21、miR-155、miR-210 和 miR-19b 是很有前途的诊断标志物。

Mol Biol Rep. 2024 Oct 3;51(1):1035. doi: 10.1007/s11033-024-09967-8.

Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma.原发性中枢神经系统淋巴瘤循环DNA中疾病特异性MYD88突变的临床意义

Cancer Sci. 2018 Jan;109(1):225-230. doi: 10.1111/cas.13450. Epub 2017 Dec 23.

Detection of circulating tumor DNA in plasma of patients with primary CNS lymphoma by digital droplet PCR.采用数字液滴 PCR 技术检测原发性中枢神经系统淋巴瘤患者血浆中的循环肿瘤 DNA。

BMC Cancer. 2024 Apr 2;24(1):407. doi: 10.1186/s12885-024-12191-z.

MYD88 (L265P) mutation is associated with an unfavourable outcome of primary central nervous system lymphoma.髓样分化因子88（L265P）突变与原发性中枢神经系统淋巴瘤的不良预后相关。

Br J Haematol. 2017 May;177(3):492-494. doi: 10.1111/bjh.14080. Epub 2016 May 10.

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The Landscape of Primary Central Nervous System Lymphoma (PCNSL): Clinicopathologic and Genomic Characteristics and Therapeutic Perspectives.原发性中枢神经系统淋巴瘤（PCNSL）概述：临床病理及基因组特征与治疗前景

Cancers (Basel). 2025 Sep 4;17(17):2909. doi: 10.3390/cancers17172909.

The Diagnostic Yield of Cerebrospinal Fluid Analysis for the Diagnosis of Primary Central Nervous System Lymphoma: A Systematic Review.脑脊液分析对原发性中枢神经系统淋巴瘤的诊断价值：一项系统评价

Cancers (Basel). 2025 Jul 15;17(14):2352. doi: 10.3390/cancers17142352.

Evaluation of MYD88 p.L265P detection by digital droplet polymerase chain reaction in cerebrospinal fluid for integrated diagnosis of primary large B-cell lymphoma of the central nervous system.采用数字液滴聚合酶链反应检测脑脊液中MYD88 p.L265P用于中枢神经系统原发性大B细胞淋巴瘤综合诊断的评估

Br J Haematol. 2025 May 25;207(1):289-93. doi: 10.1111/bjh.20167.

Reliable detection of CNS lymphoma-derived circulating tumor DNA in cerebrospinal fluid using multi-biomarker NGS profiling: insights from a real-world study.使用多生物标志物NGS分析可靠检测脑脊液中中枢神经系统淋巴瘤来源的循环肿瘤DNA：一项真实世界研究的见解

Biomark Res. 2025 May 9;13(1):71. doi: 10.1186/s40364-025-00777-z.

Guiding clinical management of patients with CNS lymphomas by minimal-invasive detection of ctDNA in cerebrospinal fluid.通过微创检测脑脊液中的ctDNA指导中枢神经系统淋巴瘤患者的临床管理。

Leukemia. 2025 May;39(5):1265-1268. doi: 10.1038/s41375-025-02583-w. Epub 2025 Apr 9.

Circulating tumor DNA in lymphoma: technologies and applications.淋巴瘤中的循环肿瘤DNA：技术与应用

J Hematol Oncol. 2025 Mar 11;18(1):29. doi: 10.1186/s13045-025-01673-7.

High-dose MTX-based polychemotherapy for primary CNS lymphoma in younger patients: Long-term efficacy of the modified Bonn protocol.基于大剂量甲氨蝶呤的多药化疗方案治疗年轻患者原发性中枢神经系统淋巴瘤：改良波恩方案的长期疗效

Neurooncol Adv. 2025 Jan 8;7(1):vdaf005. doi: 10.1093/noajnl/vdaf005. eCollection 2025 Jan-Dec.

Advanced diffusion imaging reveals microstructural characteristics of primary CNS lymphoma, allowing differentiation from glioblastoma.先进的扩散成像揭示了原发性中枢神经系统淋巴瘤的微观结构特征，有助于与胶质母细胞瘤相鉴别。

Neurooncol Adv. 2024 Jun 8;6(1):vdae093. doi: 10.1093/noajnl/vdae093. eCollection 2024 Jan-Dec.

Primary central nervous system lymphoma.原发性中枢神经系统淋巴瘤。

J Neurol. 2024 May;271(5):2906-2913. doi: 10.1007/s00415-023-12143-w. Epub 2023 Dec 19.

Utility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases.脑脊液液体活检在鉴别中枢神经系统淋巴瘤与中枢神经系统感染/脱髓鞘疾病中的应用。

Cancer Med. 2023 Aug;12(16):16972-16984. doi: 10.1002/cam4.6329. Epub 2023 Jul 27.

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MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma.

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