Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York.
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York.
Eur J Neurosci. 2019 Feb;49(4):525-532. doi: 10.1111/ejn.14264. Epub 2018 Dec 1.
Parkinson's disease (PD) is the second most common neurodegenerative disease. Two percent of the population above the age of 60 is affected by the disease. The pathological hallmarks of PD include loss of dopaminergic neurons and the presence of Lewy bodies. Mitochondrial dysfunction and oxidative stress are thought to play a pivotal role in both sporadic and familial forms of the disease. In this review we focus on the role of mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell (IPSC) models of PD.We also provide an overview of therapeutics that have been tested and some possible new therapeutics that can be tested in IPSC models of PD.
帕金森病（PD）是第二常见的神经退行性疾病。60 岁以上人群中有 2%受该病影响。PD 的病理特征包括多巴胺能神经元丧失和路易体的存在。线粒体功能障碍和氧化应激被认为在散发性和家族性疾病中都起着关键作用。在这篇综述中，我们重点关注线粒体功能障碍和氧化应激在诱导多能干细胞（iPSC）PD 模型中的作用。我们还概述了已经在 iPSC PD 模型中测试过的治疗方法和一些可能的新治疗方法。
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