在接受某些细胞毒性化疗的实体瘤患者中，乙型肝炎病毒再激活率更高：一项大型回顾性研究。
Hepatitis B Reactivation Rate Is Higher Undergoing Some Cytotoxic Chemotherapy in Patients with Solid Tumors: A Large Retrospective Study.
机构信息
Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.
Department of Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
出版信息
Chemotherapy. 2018;63(5):247-252. doi: 10.1159/000489789. Epub 2018 Nov 8.
OBJECTIVE
The reactivation rate of chronic hepatitis B virus infection in cancer patients and chemotherapy regimens thought to be associated with hepatitis reactivation were investigated.
PATIENTS AND METHODS
In all, 3,890 cancer patients were included in this study. Mortality rates, chemotherapy regimens, cancer types, number of positive hepatitis serology and reactivation rates were obtained.
RESULTS
Only 354 patients had positive hepatitis serology results (HBsAg+). Twenty-four patients (6.7%) with HBsAg positive serology had reactivation. In patients with hepatitis reactivation, the rates of usage of 5-fluorouracil (5-FU), cisplatin, cyclophosphamide, doxorubicin, steroid, rituximab, and vincristine were found to be significantly higher than corresponding rates in patients with positive hepatitis serology results but without hepatitis reactivation (p < 0.05 for all).
CONCLUSION
Increased reactivation rates were detected with usage of 5-FU, cisplatin, cyclophosphamide, doxorubicin, steroid, rituximab, and vincristine.
目的
研究癌症患者慢性乙型肝炎病毒感染的再激活率和被认为与肝炎再激活相关的化疗方案。
方法
本研究共纳入 3890 例癌症患者。获得死亡率、化疗方案、癌症类型、乙型肝炎血清学阳性数量和再激活率。
结果
仅有 354 例患者乙型肝炎血清学结果阳性（HBsAg+）。24 例 HBsAg 阳性血清学患者发生了再激活。在发生肝炎再激活的患者中，使用氟尿嘧啶（5-FU）、顺铂、环磷酰胺、多柔比星、类固醇、利妥昔单抗和长春新碱的比例明显高于乙型肝炎血清学结果阳性但无肝炎再激活的患者（均 p < 0.05）。
结论
使用氟尿嘧啶、顺铂、环磷酰胺、多柔比星、类固醇、利妥昔单抗和长春新碱会导致再激活率增加。
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