Yoshida Minoru
Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kawasaki city, Japan.
Med Mycol. 2006 Sep 1;44(Supplement_1):S185-S189. doi: 10.1080/13693780600897997.
The G-test was developed in 1992 by Obayashi et al. as a serological diagnostic test for the measurement of β-D-glucan (BDG). A multicenter clinical study demonstrated the utility of the G-test for the diagnosis of deep mycosis with a sensitivity of 90% and specificity of 100%. Determination of BDG has found wide application in Japan, particularly in the fields of hematological diseases and hematopoietic stem cell transplants. A case of invasive pulmonary aspergillosis in which BDG determination was useful for diagnosis was presented. BDG was expected to serve as an extremely useful method of screening of deep mycosis. The possibility of BDG as a surrogate marker for a presumptive therapy of patients with fever not responding to broad-spectrum antibiotics was discussed.
G试验由小林等人于1992年开发，作为一种用于检测β-D-葡聚糖（BDG）的血清学诊断试验。一项多中心临床研究证明了G试验在深部真菌病诊断中的效用，其灵敏度为90%，特异性为100%。BDG的测定在日本已得到广泛应用，尤其是在血液疾病和造血干细胞移植领域。本文介绍了一例侵袭性肺曲霉病病例，其中BDG测定对诊断有用。BDG有望成为一种极其有用的深部真菌病筛查方法。文中还讨论了BDG作为对广谱抗生素无反应的发热患者推定治疗替代标志物的可能性。
