Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Oral Oncol. 2018 Nov;86:244-250. doi: 10.1016/j.oraloncology.2018.09.025. Epub 2018 Oct 4.
Cancer of the hypopharynx is relatively rare and accounts for roughly 3% of all head and neck cancers. Unfortunately, hypopharyngeal carcinoma has one of the worst prognosis of all head and neck cancers with a reported 5-year overall survival rate of approximately 30-35%. Toxicity related to therapy, and the need for surgical salvage continue to dominate the landscape in this disease. In this article, we set out to discuss a comprehensive overview of the current management principles, recent literature and evidence based therapeutic options surrounding treatment for hypopharyngeal squamous cell carcinoma, with a special focus on the evolution of an organ sparing paradigm.
下咽癌较为罕见，约占头颈部癌症的 3%。不幸的是，与其他头颈部癌症相比，下咽癌的预后最差，据报道 5 年总生存率约为 30-35%。与治疗相关的毒性和手术挽救的需要继续主导着这种疾病的治疗。在本文中，我们旨在讨论下咽鳞癌治疗的当前管理原则、最新文献和循证治疗选择的全面概述，特别关注保留器官范式的演变。
