Frame J W, Rout P G, Browne R M
J Oral Maxillofac Surg. 1987 Sep;45(9):771-8. doi: 10.1016/0278-2391(87)90200-x.
Edentulous areas of dog jaws were augmented with solid or porous particles of hydroxylapatite (HA) alone, or combined with either finely crushed autogenous bone or plaster of paris. At the end of the experiment (24 weeks), the augmented ridges were firm and stable and covered with healthy mucosa. The ridges augmented with only porous particles of HA demonstrated a greater amount of bone ingrowth compared with the solid, dense particles. The new bone formation occurred in those parts of the implants adjacent to the underlying alveolar bone. The addition of autogenous bone to the HA particles did not enhance bony deposition, and none of the autogenous bone chips survived for 24 weeks. The amount of new bone in the ridges augmented with plaster of paris and HA was similar to the other groups, and the plaster did not interfere with healing. There was evidence of resorption of the underlying cortical bone in many of the specimens.
用单独的羟基磷灰石（HA）固体或多孔颗粒，或与细碎的自体骨或巴黎石膏混合，对狗颌骨的无牙区进行增容。在实验结束时（24周），增容后的牙槽嵴坚固稳定，覆盖着健康的黏膜。与实心、致密颗粒相比，仅用HA多孔颗粒增容的牙槽嵴显示出更多的骨向内生长。新骨形成发生在植入物邻近下方牙槽骨的部位。向HA颗粒中添加自体骨并未增强骨沉积，且没有一块自体骨碎片存活24周。用巴黎石膏和HA增容的牙槽嵴中的新骨量与其他组相似，且石膏不干扰愈合。许多标本中有下方皮质骨吸收的证据。
